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8.
Bull World Health Organ ; 42(5): 667-72, 1970.
Artigo em Inglês | MEDLINE | ID: mdl-5311056

RESUMO

The latest developments and ideas in the therapy of leprosy are discussed, the need for long-term studies being stressed. The therapeutic efficacy and effective dosages of some sulfones (especially diaphenylsulfone), thiambutosine and long-acting sulfonamides such as sulfamethoxine and sulfalene, are considered. The possibilities for two newer drugs, 4,4'-diacetyldiaminodiphenylsulfone and clofazimine (B-663), both still in the early stages of evaluation, are also described and the potential value of thalidomide in treatment of the lepra reaction is discussed. The authors make a number of recommendations for controlled trials and lines of investigation and, in particular, favour a biochemical approach to the correction of defective host defences. Diaphenylsulfone is still considered the drug of choice for use in the therapy of leprosy.


Assuntos
Anti-Infecciosos/uso terapêutico , Hanseníase/tratamento farmacológico , Compostos de Anilina/uso terapêutico , Humanos , Iminas/uso terapêutico , Fenazinas/uso terapêutico , Sulfonamidas/uso terapêutico , Sulfonas/administração & dosagem , Talidomida/uso terapêutico , Ureia/uso terapêutico
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